Prognostic Value of Vitamin D Level for All-cause Mortality, and Association With Inflammatory Markers, in HIV-infected Persons
Identifieur interne : 004001 ( Main/Exploration ); précédent : 004000; suivant : 004002Prognostic Value of Vitamin D Level for All-cause Mortality, and Association With Inflammatory Markers, in HIV-infected Persons
Auteurs : Leah Shepherd [Royaume-Uni] ; Jean-Claude Souberbielle [France] ; Jean-Philippe Bastard [France] ; Soraya Fellahi [France] ; Jaqueline Capeau [France] ; Joanne Reekie [Royaume-Uni, Australie] ; Peter Reiss [Pays-Bas] ; Anders Blaxhult [Suède] ; Markus Bickel [Allemagne] ; Clifford Leen [Royaume-Uni] ; Ole Kirk [Danemark] ; Jens D. Lundgren [Danemark] ; Amanda Mocroft [Royaume-Uni] ; Jean-Paul Viard [France]Source :
- The Journal of infectious diseases [ 0022-1899 ] ; 2014.
Descripteurs français
- Pascal (Inist)
- Homme, Vitamine D, Infection, SIDA.
- Wicri :
- topic : Homme.
English descriptors
Abstract
Background. Low 25-hydroxyvitamin D (25(OH)D) has been associated with inflammation, human immunodeficiency virus (HIV) disease progression, and death. We aimed to identify the prognostic value of 25(OH)D for AIDS, non-AIDS-defining events and death, and its association with immunological/inflammatory markers. Methods. Prospective 1-1 case-control study nested within the EuroSIDA cohort. Matched cases and controls for AIDS (n = 50 matched pairs), non-AIDS-defining (n = 63) events and death (n = 41), with plasma samples during follow-up were selected. Conditional logistic regression models investigated associations between 25(OH)D levels and annual 25(OH)D change and the probability of events. Mixed models investigated relationships between 25(OH)D levels and immunological/inflammatory markers. Results. In sum, 250 patients were included. Median time between first and last sample and last sample and event was 44.6(interquartile range [IQR]: 22.7-72.3) and 3.1(IQR: 1.4-6.4) months. Odds of death decreased by 46.0%(95% confidence interval [CI], 2.0-70.0, P=.04) for a 2-fold increase in latest 25(OH)D level. There was no association between 25(OH)D and the occurrence of AIDS or non-AIDS-defining events (P >.05). In patients with current 25(OH)D <10 ng/mL, hsIL-6 concentration increased by 4.7%(95% CI, .2,9.4, P = .04) annually after adjustment for immunological/inflammatory markers, and no change in hsCRP rate was observed (P = .76). Conclusions. Low Vitamin D predicts short term mortality in HIV-positive persons. Effectiveness of vitamin D supplementation on inflammation and patient outcomes should be investigated.
Affiliations:
- Allemagne, Australie, Danemark, France, Pays-Bas, Royaume-Uni, Suède
- Angleterre, District de Darmstadt, Grand Londres, Hesse (Land), Hollande-Septentrionale, Hovedstaden, Svealand, Écosse, Île-de-France
- Amsterdam, Copenhague, Francfort-sur-le-Main, Londres, Paris, Stockholm, Édimbourg
- Université Paris-Descartes, Université d'Amsterdam
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Le document en format XML
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Londres</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>The Kirby Institute University of New South Wales</s1><s2>Sydney, New South Wales</s2><s3>AUS</s3><sZ>6 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>The Kirby Institute University of New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Reiss, Peter" sort="Reiss, Peter" uniqKey="Reiss P" first="Peter" last="Reiss">Peter Reiss</name><affiliation wicri:level="4"><inist:fA14 i1="07"><s1>Academic Medical Centre (AMC), University of Amsterdam</s1><s2>Amsterdam</s2><s3>NLD</s3><sZ>7 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region><settlement type="city">Amsterdam</settlement></placeName><orgName type="university">Université d'Amsterdam</orgName></affiliation></author><author><name sortKey="Blaxhult, Anders" sort="Blaxhult, Anders" 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C" first="Clifford" last="Leen">Clifford Leen</name><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Edinburgh Regional Infectious Diseases Unit, Western General Hospital</s1><s2>Edinburgh</s2><s3>GBR</s3><sZ>10 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Edinburgh Infectious Diseases Edinburgh University</s1><s2>Edinburgh</s2><s3>GBR</s3><sZ>10 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Kirk, Ole" sort="Kirk, Ole" uniqKey="Kirk O" first="Ole" last="Kirk">Ole Kirk</name><affiliation wicri:level="3"><inist:fA14 i1="12"><s1>Copenhagen HIV Programme, University of Copenhagen</s1><s2>Copenhagen</s2><s3>DNK</s3><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Danemark</country><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Department of Infectious Diseases, Centre for Viral Diseases</s1><s2>Rigshospitalet, Copenhagen</s2><s3>DNK</s3><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Danemark</country><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Lundgren, Jens D" sort="Lundgren, Jens D" uniqKey="Lundgren J" first="Jens D." last="Lundgren">Jens D. Lundgren</name><affiliation wicri:level="3"><inist:fA14 i1="12"><s1>Copenhagen HIV Programme, University of Copenhagen</s1><s2>Copenhagen</s2><s3>DNK</s3><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Danemark</country><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Department of Infectious Diseases, Centre for Viral Diseases</s1><s2>Rigshospitalet, Copenhagen</s2><s3>DNK</s3><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Danemark</country><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Mocroft, Amanda" sort="Mocroft, Amanda" uniqKey="Mocroft A" first="Amanda" last="Mocroft">Amanda Mocroft</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Infection and Population Health, University College London Medical School</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Viard, Jean Paul" sort="Viard, Jean Paul" uniqKey="Viard J" first="Jean-Paul" last="Viard">Jean-Paul Viard</name><affiliation wicri:level="4"><inist:fA14 i1="14"><s1>Centre de Diagnostic et de Thérapeutique Hôtel-Dieu, APHP, and EA 3620, Université Paris Descartes</s1><s2>Paris</s2><s3>FRA</s3><sZ>14 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Paris-Descartes</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">14-0211985</idno><date when="2014">2014</date><idno type="stanalyst">PASCAL 14-0211985 INIST</idno><idno type="RBID">Pascal:14-0211985</idno><idno type="wicri:Area/PascalFrancis/Corpus">000280</idno><idno type="wicri:Area/PascalFrancis/Curation">005B82</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000137</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000137</idno><idno type="wicri:doubleKey">0022-1899:2014:Shepherd L:prognostic:value:of</idno><idno type="wicri:Area/Main/Merge">004061</idno><idno type="wicri:Area/Main/Curation">004001</idno><idno type="wicri:Area/Main/Exploration">004001</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Prognostic Value of Vitamin D Level for All-cause Mortality, and Association With Inflammatory Markers, in HIV-infected Persons</title><author><name sortKey="Shepherd, Leah" sort="Shepherd, Leah" uniqKey="Shepherd L" first="Leah" last="Shepherd">Leah Shepherd</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Infection and Population Health, University College London Medical School</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Souberbielle, Jean Claude" sort="Souberbielle, Jean Claude" uniqKey="Souberbielle J" first="Jean-Claude" last="Souberbielle">Jean-Claude Souberbielle</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Service d'Explorations Fonctionnelles, Hôpital Necker</s1><s2>Paris</s2><s3>FRA</s3><sZ>2 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Bastard, Jean Philippe" sort="Bastard, Jean Philippe" uniqKey="Bastard J" first="Jean-Philippe" last="Bastard">Jean-Philippe Bastard</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Biochemistry, Hôpital Tenon, APHP</s1><s2>Paris</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>INSERM, U938, Faculté de Médecine Saint Antoine, ICAN, Institute of Cardiometabolism and Nutrition</s1><s2>Paris</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>France</country><placeName><region 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type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>INSERM, U938, Faculté de Médecine Saint Antoine, ICAN, Institute of Cardiometabolism and Nutrition</s1><s2>Paris</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>UPMC Univ Paris 06, UMR_S 938</s1><s2>Paris</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Capeau, Jaqueline" sort="Capeau, Jaqueline" uniqKey="Capeau J" first="Jaqueline" last="Capeau">Jaqueline Capeau</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Biochemistry, Hôpital Tenon, APHP</s1><s2>Paris</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>INSERM, U938, Faculté de Médecine Saint Antoine, ICAN, Institute of Cardiometabolism and Nutrition</s1><s2>Paris</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>UPMC Univ Paris 06, UMR_S 938</s1><s2>Paris</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Reekie, Joanne" sort="Reekie, Joanne" uniqKey="Reekie J" first="Joanne" last="Reekie">Joanne Reekie</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Infection and Population Health, University College London Medical School</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>The Kirby Institute University of New South Wales</s1><s2>Sydney, New South Wales</s2><s3>AUS</s3><sZ>6 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>The Kirby Institute University of New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Reiss, Peter" sort="Reiss, Peter" uniqKey="Reiss P" first="Peter" last="Reiss">Peter Reiss</name><affiliation wicri:level="4"><inist:fA14 i1="07"><s1>Academic Medical Centre (AMC), University of Amsterdam</s1><s2>Amsterdam</s2><s3>NLD</s3><sZ>7 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region><settlement type="city">Amsterdam</settlement></placeName><orgName type="university">Université d'Amsterdam</orgName></affiliation></author><author><name sortKey="Blaxhult, Anders" sort="Blaxhult, Anders" uniqKey="Blaxhult A" first="Anders" last="Blaxhult">Anders Blaxhult</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Department of Medicine, Division of Infectious Diseases, Karolinska Institute</s1><s2>Stockholm</s2><s3>SWE</s3><sZ>8 aut.</sZ></inist:fA14><country>Suède</country><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Bickel, Markus" sort="Bickel, Markus" uniqKey="Bickel M" first="Markus" last="Bickel">Markus Bickel</name><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>HIVCENTER Haus 68</s1><s2>Frankfurt</s2><s3>DEU</s3><sZ>9 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName></affiliation></author><author><name sortKey="Leen, Clifford" sort="Leen, Clifford" uniqKey="Leen C" first="Clifford" last="Leen">Clifford Leen</name><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Edinburgh Regional Infectious Diseases Unit, Western General Hospital</s1><s2>Edinburgh</s2><s3>GBR</s3><sZ>10 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Edinburgh Infectious Diseases Edinburgh University</s1><s2>Edinburgh</s2><s3>GBR</s3><sZ>10 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Kirk, Ole" sort="Kirk, Ole" uniqKey="Kirk O" first="Ole" last="Kirk">Ole Kirk</name><affiliation wicri:level="3"><inist:fA14 i1="12"><s1>Copenhagen HIV Programme, University of Copenhagen</s1><s2>Copenhagen</s2><s3>DNK</s3><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Danemark</country><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Department of Infectious Diseases, Centre for Viral Diseases</s1><s2>Rigshospitalet, Copenhagen</s2><s3>DNK</s3><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Danemark</country><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Lundgren, Jens D" sort="Lundgren, Jens D" uniqKey="Lundgren J" first="Jens D." last="Lundgren">Jens D. Lundgren</name><affiliation wicri:level="3"><inist:fA14 i1="12"><s1>Copenhagen HIV Programme, University of Copenhagen</s1><s2>Copenhagen</s2><s3>DNK</s3><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Danemark</country><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Department of Infectious Diseases, Centre for Viral Diseases</s1><s2>Rigshospitalet, Copenhagen</s2><s3>DNK</s3><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Danemark</country><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Mocroft, Amanda" sort="Mocroft, Amanda" uniqKey="Mocroft A" first="Amanda" last="Mocroft">Amanda Mocroft</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Infection and Population Health, University College London Medical School</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Viard, Jean Paul" sort="Viard, Jean Paul" uniqKey="Viard J" first="Jean-Paul" last="Viard">Jean-Paul Viard</name><affiliation wicri:level="4"><inist:fA14 i1="14"><s1>Centre de Diagnostic et de Thérapeutique Hôtel-Dieu, APHP, and EA 3620, Université Paris Descartes</s1><s2>Paris</s2><s3>FRA</s3><sZ>14 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Paris-Descartes</orgName></affiliation></author></analytic><series><title level="j" type="main">The Journal of infectious diseases</title><title level="j" type="abbreviated">J. infect. dis.</title><idno type="ISSN">0022-1899</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">The Journal of infectious diseases</title><title level="j" type="abbreviated">J. infect. dis.</title><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>AIDS</term><term>Human</term><term>Infection</term><term>Vitamin D</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Homme</term><term>Vitamine D</term><term>Infection</term><term>SIDA</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background. Low 25-hydroxyvitamin D (25(OH)D) has been associated with inflammation, human immunodeficiency virus (HIV) disease progression, and death. We aimed to identify the prognostic value of 25(OH)D for AIDS, non-AIDS-defining events and death, and its association with immunological/inflammatory markers. Methods. Prospective 1-1 case-control study nested within the EuroSIDA cohort. Matched cases and controls for AIDS (n = 50 matched pairs), non-AIDS-defining (n = 63) events and death (n = 41), with plasma samples during follow-up were selected. Conditional logistic regression models investigated associations between 25(OH)D levels and annual 25(OH)D change and the probability of events. Mixed models investigated relationships between 25(OH)D levels and immunological/inflammatory markers. Results. In sum, 250 patients were included. Median time between first and last sample and last sample and event was 44.6(interquartile range [IQR]: 22.7-72.3) and 3.1(IQR: 1.4-6.4) months. Odds of death decreased by 46.0%(95% confidence interval [CI], 2.0-70.0, P=.04) for a 2-fold increase in latest 25(OH)D level. There was no association between 25(OH)D and the occurrence of AIDS or non-AIDS-defining events (P >.05). In patients with current 25(OH)D <10 ng/mL, hsIL-6 concentration increased by 4.7%(95% CI, .2,9.4, P = .04) annually after adjustment for immunological/inflammatory markers, and no change in hsCRP rate was observed (P = .76). Conclusions. Low Vitamin D predicts short term mortality in HIV-positive persons. Effectiveness of vitamin D supplementation on inflammation and patient outcomes should be investigated.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Danemark</li><li>France</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Suède</li></country><region><li>Angleterre</li><li>District de Darmstadt</li><li>Grand Londres</li><li>Hesse (Land)</li><li>Hollande-Septentrionale</li><li>Hovedstaden</li><li>Svealand</li><li>Écosse</li><li>Île-de-France</li></region><settlement><li>Amsterdam</li><li>Copenhague</li><li>Francfort-sur-le-Main</li><li>Londres</li><li>Paris</li><li>Stockholm</li><li>Édimbourg</li></settlement><orgName><li>Université Paris-Descartes</li><li>Université d'Amsterdam</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Shepherd, Leah" sort="Shepherd, Leah" uniqKey="Shepherd L" first="Leah" last="Shepherd">Leah Shepherd</name></region><name sortKey="Leen, Clifford" sort="Leen, Clifford" uniqKey="Leen C" first="Clifford" last="Leen">Clifford Leen</name><name sortKey="Leen, Clifford" sort="Leen, Clifford" uniqKey="Leen C" first="Clifford" last="Leen">Clifford Leen</name><name sortKey="Mocroft, Amanda" sort="Mocroft, Amanda" uniqKey="Mocroft A" first="Amanda" last="Mocroft">Amanda Mocroft</name><name sortKey="Reekie, Joanne" sort="Reekie, Joanne" uniqKey="Reekie J" first="Joanne" last="Reekie">Joanne Reekie</name></country><country name="France"><region name="Île-de-France"><name sortKey="Souberbielle, Jean Claude" sort="Souberbielle, Jean Claude" uniqKey="Souberbielle J" first="Jean-Claude" last="Souberbielle">Jean-Claude Souberbielle</name></region><name sortKey="Bastard, Jean Philippe" sort="Bastard, Jean Philippe" uniqKey="Bastard J" first="Jean-Philippe" last="Bastard">Jean-Philippe Bastard</name><name sortKey="Bastard, Jean Philippe" sort="Bastard, Jean Philippe" uniqKey="Bastard J" first="Jean-Philippe" last="Bastard">Jean-Philippe Bastard</name><name sortKey="Bastard, Jean Philippe" sort="Bastard, Jean Philippe" uniqKey="Bastard J" first="Jean-Philippe" last="Bastard">Jean-Philippe Bastard</name><name sortKey="Capeau, Jaqueline" sort="Capeau, Jaqueline" uniqKey="Capeau J" first="Jaqueline" last="Capeau">Jaqueline Capeau</name><name sortKey="Capeau, Jaqueline" sort="Capeau, Jaqueline" uniqKey="Capeau J" first="Jaqueline" last="Capeau">Jaqueline Capeau</name><name sortKey="Capeau, Jaqueline" sort="Capeau, Jaqueline" uniqKey="Capeau J" first="Jaqueline" last="Capeau">Jaqueline Capeau</name><name sortKey="Fellahi, Soraya" sort="Fellahi, Soraya" uniqKey="Fellahi S" first="Soraya" last="Fellahi">Soraya Fellahi</name><name sortKey="Fellahi, Soraya" sort="Fellahi, Soraya" uniqKey="Fellahi S" first="Soraya" last="Fellahi">Soraya Fellahi</name><name sortKey="Fellahi, Soraya" sort="Fellahi, Soraya" uniqKey="Fellahi S" first="Soraya" last="Fellahi">Soraya Fellahi</name><name sortKey="Viard, Jean Paul" sort="Viard, Jean Paul" uniqKey="Viard J" first="Jean-Paul" last="Viard">Jean-Paul Viard</name></country><country name="Australie"><noRegion><name sortKey="Reekie, Joanne" sort="Reekie, Joanne" uniqKey="Reekie J" first="Joanne" last="Reekie">Joanne Reekie</name></noRegion></country><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Reiss, Peter" sort="Reiss, Peter" uniqKey="Reiss P" first="Peter" last="Reiss">Peter Reiss</name></region></country><country name="Suède"><region name="Svealand"><name sortKey="Blaxhult, Anders" sort="Blaxhult, Anders" uniqKey="Blaxhult A" first="Anders" last="Blaxhult">Anders Blaxhult</name></region></country><country name="Allemagne"><region name="Hesse (Land)"><name sortKey="Bickel, Markus" sort="Bickel, Markus" uniqKey="Bickel M" first="Markus" last="Bickel">Markus Bickel</name></region></country><country name="Danemark"><region name="Hovedstaden"><name sortKey="Kirk, Ole" sort="Kirk, Ole" uniqKey="Kirk O" first="Ole" last="Kirk">Ole Kirk</name></region><name sortKey="Kirk, Ole" sort="Kirk, Ole" uniqKey="Kirk O" first="Ole" last="Kirk">Ole Kirk</name><name sortKey="Lundgren, Jens D" sort="Lundgren, Jens D" uniqKey="Lundgren J" first="Jens D." last="Lundgren">Jens D. Lundgren</name><name sortKey="Lundgren, Jens D" sort="Lundgren, Jens D" uniqKey="Lundgren J" first="Jens D." last="Lundgren">Jens D. Lundgren</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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